Aberrant immunophenotypes in acute lymphoblastic leukemia



Miguel E. Cuéllar-Mendoza, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
Francisco R. Chávez-Sánchez, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
Elisa Dorantes-Acosta, Biobanco de Investigación en Células Leucémicas, Hospital Infantil de México Federico Gómez, Ciudad de México, México
Blanca M. Arsuaga-Jiménez, Departamento de Oncología, Instituto Nacional de Pediatría, Mexico City, Mexico
Marta Zapata-Tarrés, Departamento de Oncología Médica, Instituto Nacional de Pediatría, Secretaría de Salud, Cuidad de México. México


Acute lymphoblastic leukemia (ALL) is the most prevalent hematologic neoplasia worldwide. To classify leukemia, the immunophenotypic characteristics in the neoplastic cells obtained with antibodies are analyzed by cell flow cytometry or immunohistochemistry. The aberrant immunophenotypes are antigen expression patterns that differ from the normal hematopoietic maturation process, which can include some different lineage antigens such as myeloid antigens in ALL or asynchronous expression of antigens. These aberrant immunophenotypes have been studied as prognostic factors and residual disease markers. In this review, some aspects of aberrant immunophenotypes are addressed, including definition, epidemiology, and potential uses.



Keywords: Immunophenotypes. Leukemia. Lymphoblastic. Hematologic. Review.