Vitamin D concentration and its association with parathyroid hormone in children and adolescents



Patricia Clark, Unidad de Epidemiología Clínica, Hospital Infantil de México Federico Gómez; Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
Diana Montiel-Ojeda, Unidad de Epidemiología Clínica, Hospital Infantil de México Federico Gómez; Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
Laura G. Chico-Barba, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
Desirée López-González, Unidad de Epidemiología Clínica, Hospital Infantil de México Federico Gómez; Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México
Lucía Méndez-Sánchez, Unidad de Epidemiología Clínica, Hospital Infantil Federico Gómez; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
Miguel A. Guagnelli-Martínez, Unidad de Epidemiología Clínica, Hospital Infantil Federico Gómez; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico


Background: Vitamin D (VD) deficiency has been inversely associated with parathyroid hormone (PTH) levels in the adult population but not in children and adolescents. This study aimed to report VD concentration and its correlation with PTH levels in a sample of healthy Mexican children. Methods: We conducted a cross-sectional study with 275 healthy Mexican subjects aged 2 to 17 years to estimate the status of 25-(OH)-D and its correlation with PTH levels. The 25-(OH)-D levels were estimated by liquid chromatography-tandem mass spectrometry and PTH by radioimmunoassay. Results: Subjects were categorized as young children (2 to 5 years), school children (6 to 10 years), and adolescents (11 to 17 years). The median concentration of 25-(OH)-D in young children was 27.4 ng/ml; in school children, 25.6 ng/ml; and adolescents, 24.7 ng/ml. VD levels < 20 ng/ml were found in only 10.5% of the participants. Only 3% of the young children showed VD deficiency, in contrast to 10% of school children and 21% of adolescents (p ≤ 0.05). PTH was found within normal ranges in 95.6% ofthe studied population. VD levels < 20 mg/dl were found in 25.8% of children with overweight or obesity (p = 0.009).Conclusions: VD levels < 20 ng/ml were observed in 10% of the studied group, but this percentage increased with age:21% of the adolescents showed VD levels < 20 ng/ml. No correlation with PTH levels was found. The VD values reported inthis study are lower than those previously reported in Mexican children.



Keywords: Vitamin D. Parathyroid hormone. Pediatrics.